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CC Madhya 8.248

‘দুঃখ-মধ্যে কোন দুঃখ হয় গুরুতর?’
‘কৃষ্ণভক্ত-বিরহ বিনা দুঃখ নাহি দেখি পর ॥’ ২৪৮ ॥
‘duḥkha-madhye kona duḥkha haya gurutara?’
‘kṛṣṇa-bhakta-viraha vinā duḥkha nāhi dekhi para’

Synonyms

duḥkha-madhyeamong the miserable conditions of life; konawhat; duḥkhamisery; hayais; gurutaramore painful; kṛṣṇa-bhakta-virahaseparation from the devotee of Lord Kṛṣṇa; vinābesides; duḥkhaunhappiness; nāhithere is not; dekhiI see; paraother.

Translation

Śrī Caitanya Mahāprabhu asked, “Of all kinds of distress, what is the most painful?”
Śrī Rāmānanda Rāya replied, “Apart from separation from the devotee of Kṛṣṇa, I know of no unbearable unhappiness.”

Purport

Concerning this, the Lord states in the Vedic literature:
mām anārādhya duḥkhārtaḥkuṭumbāsakta-mānasaḥ
sat-saṅga-rahito martyo
vṛddha-sevā-paricyutaḥ
“A person who does not worship Me, who is unduly attached to family and who does not stick to devotional service must be considered a most unhappy person. Similarly, one who does not associate with Vaiṣṇavas, or who does not render service to his superior, is also a most unhappy person.”
There is also the following statement in the Bṛhad-bhāgavatāmṛta (1.5.54):
sva-jīvanādhikaṁ prārthyaṁśrī-viṣṇu-jana-saṅgataḥ
vicchedena kṣaṇaṁ cātra
na sukhāṁśaṁ labhāmahe
“Out of all kinds of desirable things experienced in the life of a living entity, association with the devotees of the Lord is the greatest. When we are separated from a devotee even for a moment, we cannot enjoy happiness.”