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ŚB 11.25.35

सत्त्वं चाभिजयेद् युक्तो नैरपेक्ष्येण शान्तधी: ।
सम्पद्यते गुणैर्मुक्तो जीवो जीवं विहाय माम् ॥ ३५ ॥
sattvaṁ cābhijayed yukto
nairapekṣyeṇa śānta-dhīḥ
sampadyate guṇair mukto
jīvo jīvaṁ vihāya mām

Synonyms

sattvamthe mode of goodness; caalso; abhijayethe should conquer; yuktaḥengaged in devotional service; nairapekṣyeṇaby being indifferent to the modes; śāntapacified; dhīḥwhose intelligence; sampadyatehe achieves; guṇaiḥfrom the modes of nature; muktaḥliberated; jīvaḥthe living entity; jīvamthe cause of his being conditioned; vihāyagiving up; māmMe.

Translation

Then, being fixed in devotional service, the sage should also conquer the material mode of goodness by indifference toward the modes. Thus pacified within his mind, the spirit soul, freed from the modes of nature, gives up the very cause of his conditioned life and attains Me.

Purport

The word nairapekṣyeṇa refers to complete detachment from the modes of material nature. By attachment to the loving service of the Lord, which is completely transcendental, one gives up one’s interest in the modes of nature.